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![]() Sharon flashes back to the moment where she told Swayam that if she dances, then it would mean she has no feelings for him. If she uses the inhaler 4 hours prior taking any stress, then it could work. She then makes her sit down and explains to Sharon that she knows she’s worried about how to escape the group dance tomorrow and that she researched online. Simmi comes to her aid and gives her the inhaler. ![]() Outside, she gets attack as she is running to get away from Swayam. She walks away from there, leaving Swayam confused and gloomy. ![]() She has no answers and she has his back faced to him, trying to hide in her tears as it’s hard for her as well to stay away from him but that is the only option she has so that he doesn’t give up his passion too for her. “Why can’t I touch you? Why can’t I see you? Why does your heart beats faster when I come near you? Why Sharon? He questions her why her eyes says something and she says the opposite. Swayam catches that and Sharon turns to leave once again but Swayam stops her way. Indirectly, saying that if she doesn’t dance, then she has feelings for him. Then she asks if he’ll be satisfied if she dances as that will prove that she has no feelings for him. She turns with attitude and warms him to not give himself so much importance. When she turns to leave, Swayam asks if she isn’t dancing because of him. To which, Swayam cheekily replies, My pleasure. When asked for what, she replies pointing at the wound. Swayam asks, ‘So?” Sharon continues and in a bare whisper, says sorry. She makes up an excuse that she was here to see the props as they had them here last year. Sharon cannot continue to watch this, hesitates and thus turns to leaves when her heels make a sound, ending in Swayam turning and seeing her. Just as she knew where he would be, she lands up there and watches him burn in pain as he applies medicine and telling himself that he’s ready to take this pain as the marks are signs from Sharon. Nevertheless, Sharon gets up from there and leaves. Rey tells Taani to relax and not worry as Swayam isn’t a delicate girl. ![]() Sharon is immediately concerned and tries not to show it to others. Taani shows them the shirt tells them all that she’s worried as she saw blood on his shirt. Rey informs her he was looking for medical. They all enjoy when Taani rushes there to ask if anyone has Swayam. Sharon comes then and yells at them before giving them all coffee and asking them to chill. Inside, the girls and boys are shouting at each other and arguing like cats and dogs. Taani pulls her in when she sees her standing by herself. swayam grins to self and goes in with rest of them to play in the water.Īll the while, Aashi was looking at SwaRon and a bit hurt even after knowing Swayam and Sharon are meant to be. Swayam asks if she’s concerned for him and she replies back with ‘Concern my foot’ and leaves from there. The song actually starts playing when Sharon moves her head back to look at him and apologizes. Everyone in the back ground sings Baahon Ke darmiyaan as Swayam hesitates on putting his arms around her and stays rooted. Swayam tells Rey to let go after holding Sharon’s hand and instantly, Rey let’s her go resulting in Sharon crashing into Swayam and hugging him. Dil Dosti Dance 13th February 2013 Written Episode, Dil Dosti Dance 13th February 2013 Written UpdateĮpisode resumes with Sharon trying to escape Rey’s hold and grabbing on to Swayam as a result. ![]() ![]() BET acetyl-lysine binding proteins control pathological cardiac hypertrophy. BET bromodomains mediate transcriptional pause release in heart failure. Fibrosis-a common pathway to organ injury and failure. The plasticity and specificity of BET-dependent regulation of MEOX1 in tissue fibroblasts provide previously unknown trans- and cis-targets for treating fibrotic disease. We identify MEOX1 as a central regulator of fibroblast activation associated with cardiac dysfunction and demonstrate its upregulation after activation of human lung, liver and kidney fibroblasts. Selective CRISPR inhibition of the single most dynamic cis-element within the enhancer blocked TGFβ-induced Meox1 activation. Among the most dynamic elements was an enhancer that regulated the transcription factor MEOX1, which was specifically expressed in activated fibroblasts, occupied putative regulatory elements of a broad fibrotic gene program and was required for TGFβ-induced fibroblast activation. ![]() Single-cell chromatin accessibility revealed previously undescribed DNA elements, the accessibility of which dynamically correlated with cardiac performance. ![]() Resident cardiac fibroblasts demonstrated robust toggling between the quiescent and activated state in a manner directly correlating with BET inhibitor exposure and cardiac function. Here we use single-cell epigenomic analyses of hearts dynamically exposed to BET inhibitors to reveal a reversible transcriptional switch that underlies the activation of fibroblasts. Pharmacological inhibition of bromodomain and extra-terminal domain (BET) proteins alleviates cardiac dysfunction 3, 4, 5, 6, 7, providing a tool to interrogate and modulate cardiac cell states as a potential therapeutic approach. Fibroblast activation is a common stress response in tissues that worsens lung, liver, kidney and heart disease, yet its mechanistic basis remains unclear 1, 2. In diseased organs, stress-activated signalling cascades alter chromatin, thereby triggering maladaptive cell state transitions. Nature volume 595, pages 438–443 ( 2021) Cite this article ![]() A transcriptional switch governs fibroblast activation in heart disease ![]() ![]() ![]()
![]() ![]() Of course, both WebRTC SFU are amazing work!! I'm using both. From these points, janus is suitable for webinar, jitsi is for web conference. Jitsi last-n + VP8 simulcasting has the very good performance for web conference For the video format, janus recording is per video streaming, jitsi is for mixed video conference by using chrome headlesss + ffmpeg(alsa, libxcb). The scalability of the current Jitsi Video Bridge(20181007) is poor because of having no local recording file(I'm not sure of this.). ![]() ![]() I think that janus is better for webinar(web seminar), and jitsi is better for web conference system. About the details of setup for this docker image, you should read the official docs carefully. If you need any request about this repo, free to contact me. I try to deal with such a chage as much as I can. So, as the official docs says, some minor modification of the middleware library versions happens frequently. 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